MECHANISM-DISCOVERY EXERCISE
How does a single ORC load two helicases?
Build physical loading intermediates, trigger individual ATPase events, and compare what your model produces with structural and single-molecule observations. A successful endpoint is not enough: the path must distinguish one-ORC loading from alternative mechanisms.
WHAT IS KNOWN
Loading order seen one molecule at a time
The predominant one-ORC pathway is shown as observed arrivals and departures. The highlighted event is the next observation not yet reproduced by your model.
Open investigation
Assemble a candidate loading pathway
Drag molecules into the chamber, or select one and click a position. No action is disabled.
No alternative-route events have been invoked.
MECHANISM QUESTIONS
Explain what the loading pathway reveals
Use your model and the structures you revealed. Each response is evaluated independently by an automated feedback service.
Submitted answer text is processed only to generate feedback. Do not include personal or sensitive information.